Seven-Day Pedometer-Assessed Step Counts and Brain Volume: A Population-Based Observational Study

To investigate the association between step counts and brain volumes (BVs)-global and 6 a priori selected cognition-related regions of interest-in Japanese men aged 40-79 years. The authors analyzed data from 680 cognitively intact participants of the Shiga Epidemiological Study of Subclinical Ather...

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Published inJournal of physical activity & health Vol. 18; no. 2; p. 157
Main Authors Moniruzzaman, Mohammad, Kadota, Aya, Shiino, Akihiko, Fujiyoshi, Akira, Ito, Takahiro, Haidar Syaifullah, Ali, Miyagawa, Naoko, Kondo, Keiko, Hisamatsu, Takashi, Segawa, Hiroyoshi, Tooyama, Ikuo, Ueshima, Hirotsugu, Miura, Katsuyuki
Format Journal Article
LanguageEnglish
Published United States 01.02.2021
Subjects
Actigraphy
Aged
Brain - diagnostic imaging
Cognition
Cross-Sectional Studies
Health Status
Humans
Male
Prefrontal Cortex
healthy brain aging
step activity
age-related brain volume
brain volume related to cognition
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Summary:To investigate the association between step counts and brain volumes (BVs)-global and 6 a priori selected cognition-related regions of interest-in Japanese men aged 40-79 years. The authors analyzed data from 680 cognitively intact participants of the Shiga Epidemiological Study of Subclinical Atherosclerosis-a population-based observational study. Using multivariable linear regression, the authors assessed cross-sectional associations between 7-day step counts at baseline (2006-2008) and BVs at follow-up (2012-2015) for age-stratified groups (<60 y and ≥60 y). In the older adults ≥60 years, step counts at baseline (per 1000 steps) were associated with total BV at follow-up (β = 1.42, P = .022) while adjusted for potential covariates. Regions of interest-based analyses yielded an association of step counts with both prefrontal cortexes (P < .05) in older adults, while the left entorhinal cortex showed marginally significant association (P = .05). No association was observed with hippocampus, parahippocampal, cingulum, and cerebellum. No association was observed in younger adults (<60 y). The authors found a positive association between 7-day step counts and BVs, including prefrontal cortexes, and left entorhinal cortex in apparently healthy Japanese men.
ISSN:1543-5474
DOI:10.1123/jpah.2019-0659