Treatment of liver cirrhosis with microsomal enzyme-inducing compound in the rat

• Published in: Journal of hepatology Vol. 1; no. 5; pp. 501 - 511
• Main Authors: Saarni, Hannu U., Arranto, Arno J., Rautio, Arja, Sotaniemi, Eero A.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier B.V 1985; Elsevier
• Subjects: Aminopyrine N-Demethylase - metabolism; Animals; Biological and medical sciences; Cytochrome P-450 Enzyme System - metabolism; Cytochrome Reductases - metabolism; Digestive system; DNA - metabolism; Enzyme Induction - drug effects; Liver Cirrhosis - drug therapy; Liver Function Tests; Male; Medical sciences; Medroxyprogesterone - analogs & derivatives; Medroxyprogesterone - therapeutic use; Medroxyprogesterone Acetate; Microsomes, Liver - enzymology; Pharmacology. Drug treatments; Proteins - metabolism; Rats; Digestive diseases; Animal
• ISSN: 0168-8278; 1600-0641
• DOI: 10.1016/S0168-8278(85)80748-0

The effect of therapy with a microsomal enzyme-inducing drug on the cirrhotic liver in male Wistar rats was investigated by morphological and biochemical means. The cirrhotic animals were treated with medroxyprogesterone acetate (MPA) 100 mg/kg body wt, i.p. daily for a week. In the cirrhotic rats liver weight was enhanced, liver protein content was increased while total liver DNA content remained unchanged upon MPA treatment. The hepatic regenerative nodule size increased, as determined by morphological means. Hepatic microsomal metabolic activity was improved, as seen by increases in NADPH-cytochrome P-450 reductase and aminopyrine N-demethylase activities and cytochrome P-450 content. Since the increases in liver protein content and metabolic activity were relatively greater in the cirrhotic than intact animals upon MPA treatment, it was suggested that the spontaneous regeneration associated with liver cirrhosis may affect the induction phenomenon. The results demonstrate that an enzyme inducer may have beneficial effects on the cirrhotic liver by elevating metabolic activity and parenchymal mass.