Boric-acid-modified Fe3O4@PDA@UiO-66 for enrichment and detection of glucose by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

• Published in: Analytical and bioanalytical chemistry Vol. 412; no. 29; pp. 8083 - 8092
• Main Authors: Li, Zhijian, Huo, Panpan, Gong, Congcong, Deng, Chunhui, Pu, Shouzhi
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2020; Springer Nature B.V
• Subjects: Acids; Analytical Chemistry; Biochemistry; Boric acid; Characterization and Evaluation of Materials; Chemical synthesis; Chemistry; Chemistry and Materials Science; Desorption; Food Science; Glucose; Hydrothermal reactions; Ionization; Ions; Iron oxides; Laboratory Medicine; Mass spectrometry; Mass spectroscopy; Metal-organic frameworks; Monitoring/Environmental Analysis; Porous media; Research Paper; Scientific imaging; Spectroscopy; Zirconium; Enrichment; Boric acid; MALDI-TOF MS; Metal-organic framework; Glucose
• ISSN: 1618-2642; 1618-2650
• DOI: 10.1007/s00216-020-02935-8

Herein, boric-acid-modified multifunctional Zr-based metal-organic frameworks (denoted as Fe 3 O 4 @PDA@B-UiO-66) were synthesized by hydrothermal reaction and surface modification. Compared to traditional matrix, Fe 3 O 4 @PDA@B-UiO-66 has the advantages of high ionization efficiency, high surface area, low matrix background, porous structure, and numerous boric-acid-active sites. By combining matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), Fe 3 O 4 @PDA@B-UiO-66 was used as an adsorbent and matrix for enrichment and detection of glucose, based on a specific reaction between boric acid and glucose. The limit of detection was 58.5 nM. The proposed method provides a simple and efficient approach for the sensitive and quantitative detection of glucose in complex samples based on MALDI-TOF MS. Design and synthesis of boric-acid-modified multifunctional magnetic metal-organic frameworks (designated as Fe 3 O 4 @PDA@B-UiO-66) applied as adsorbent and matrix for the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) analysis of glucose in complex biosamples.