Colchicine in the treatment of AA and AL amyloidosis

Colchicine is an effective medication in the prevention and treatment of amyloidosis of familial Mediterranean fever. Its therapeutic effect depends on the stage of renal disease and the drug dose. To evaluate colchicine effect in AA amyloidosis of other diseases and in primary AL amyloidosis; the l...

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Published inSeminars in arthritis and rheumatism Vol. 23; no. 3; pp. 206 - 214
Main Authors Livneh, Avi, Zemer, Deborah, Langevitz, Pnina, Shemer, Joshua, Sohar, Ezra, Pras, Mordechai
Format Journal Article
LanguageEnglish
Published Philadelphia, PA Elsevier Inc 01.12.1993
Elsevier
Subjects
Adult
amyloid A
amyloid L
Amyloidosis
Amyloidosis - classification
Amyloidosis - etiology
Amyloidosis - prevention & control
Biological and medical sciences
Child
colchicine
Colchicine - therapeutic use
familial Mediterranean fever
Familial Mediterranean Fever - complications
Female
General and cellular metabolism. Vitamins
Humans
Male
Medical sciences
Middle Aged
Nephrotic Syndrome - drug therapy
Pharmacology. Drug treatments
Treatment Outcome
colchicine
Amyloidosis
familial Mediterranean fever
amyloid A
amyloid L
Human
Chemotherapy
Treatment
Systemic disease
Metabolic diseases
Light peptide chain
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Summary:Colchicine is an effective medication in the prevention and treatment of amyloidosis of familial Mediterranean fever. Its therapeutic effect depends on the stage of renal disease and the drug dose. To evaluate colchicine effect in AA amyloidosis of other diseases and in primary AL amyloidosis; the literature was reviewed. Findings were that (1) the effect of colchicine in reactive amyloidosis has not been methodically studied, but anecdotal reports suggest it may be beneficial; and (2) the results of studies and case reports on the effect of colchicine in primary amyloidosis are conflicting. Because a therapeutic effect of colchicine in primary and reactive amyloidosis has been shown in sporadic cases, a prospective, controlled, multicenter study assessing the effect of colchicine in all types of amyloidosis appears to be justified. Until such a study is available, the addition of colchicine in an appropriate dose to any therapeutic regimen of patients with AA or AL amyloidosis should be considered.
Bibliography:ObjectType-Case Study-3
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ObjectType-Feature-5
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ISSN:0049-0172
1532-866X
DOI:10.1016/S0049-0172(05)80042-3