p53, cancer and the immune response

The importance of cancer-cell-autonomous functions of the tumour suppressor p53 (encoded by ) has been established in many studies, but it is now clear that the p53 status of the cancer cell also has a profound impact on the immune response. Loss or mutation of p53 in cancers can affect the recruitm...

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Bibliographic Details
Published inJournal of cell science Vol. 133; no. 5
Main Authors Blagih, Julianna, Buck, Michael D, Vousden, Karen H
Format Journal Article
LanguageEnglish
Published England 01.03.2020
Subjects
Humans
Immunity
Mutation
Neoplasms - genetics
Tumor Suppressor Protein p53 - genetics
Immune response
Cancer
p53
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Summary:The importance of cancer-cell-autonomous functions of the tumour suppressor p53 (encoded by ) has been established in many studies, but it is now clear that the p53 status of the cancer cell also has a profound impact on the immune response. Loss or mutation of p53 in cancers can affect the recruitment and activity of myeloid and T cells, allowing immune evasion and promoting cancer progression. p53 can also function in immune cells, resulting in various outcomes that can impede or support tumour development. Understanding the role of p53 in tumour and immune cells will help in the development of therapeutic approaches that can harness the differential p53 status of cancers compared with most normal tissue.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0021-9533
1477-9137
DOI:10.1242/jcs.237453