Genetic control of plasma cholesterol response in the rat

The inheritance of the susceptibility for dietary cholesterol in the rat has been studied by testing the plasma cholesterol response in male animals from crosses between hyperresponding and hyporesponding inbred strains. Comparison of the variances of the response of genetically uniform groups (pare...

Full description

Saved in:
Bibliographic Details
Published inThe Journal of heredity Vol. 74; no. 3; p. 211
Main Authors van Zutphen, L F, den Bieman, M G
Format Journal Article
LanguageEnglish
Published United States 01.05.1983
Subjects
Animals
Cholesterol - blood
Cholesterol, Dietary - metabolism
Crosses, Genetic
Female
Lipid Metabolism, Inborn Errors - blood
Lipid Metabolism, Inborn Errors - genetics
Male
Mathematics
Models, Genetic
Rats
Rats, Inbred Strains
Online AccessGet more information

Cover

More Information
Summary:The inheritance of the susceptibility for dietary cholesterol in the rat has been studied by testing the plasma cholesterol response in male animals from crosses between hyperresponding and hyporesponding inbred strains. Comparison of the variances of the response of genetically uniform groups (parental strains and F1 hybrid) and segregating groups (backcrosses and F2 hybrid) revealed that more than 80 percent of the observed variation can be attributed to additive genetic factors and indicated that two major genes are involved in the control of the plasma cholesterol response.
ISSN:0022-1503
DOI:10.1093/oxfordjournals.jhered.a109771