The mass spectrometry of taxol

The antitumor agent taxol has been examined by electron ionization, chemical ionization, and fast atom bombardment mass spectrometry. Three ion series are observed: (1) the M-series, characteristic of the intact molecule; (2) the T-series, with fragments derived from the taxane ring; and (3) the S-s...

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Bibliographic Details
Published inJournal of the American Society for Mass Spectrometry Vol. 3; no. 6; pp. 672 - 679
Main Authors McClure, Thomas D., Schram, Karl H., Reimer, Mark L.J.
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.09.1992
Elsevier Science
Subjects
Antineoplastic agents
Biological and medical sciences
Medical sciences
Pharmacology. Drug treatments
Antineoplastic agent
Diterpene
FAB mass spectrum
Molecular structure
Molecular weight
Fragmentation
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Summary:The antitumor agent taxol has been examined by electron ionization, chemical ionization, and fast atom bombardment mass spectrometry. Three ion series are observed: (1) the M-series, characteristic of the intact molecule; (2) the T-series, with fragments derived from the taxane ring; and (3) the S-series representing the C-13 side chain. Neutral losses dominate each series of ions and serve to verify the presence and number of functionalities in each portion of the molecule. Fragmentation pathways and mechanisms of ion formation are proposed on the basis of product ion analysis and accurate mass measurements.
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ISSN:1044-0305
1879-1123
DOI:10.1016/1044-0305(92)85009-9