Episodic secretory patterns of immunoreactive luteinizing hormone-releasing hormone (IR-LH-RH) in the systemic circulation of normal women throughout the menstrual cycle

Using established radioimmunoassays for measuring plasma luteinizing hormone-releasing hormone (LH-RH) and serum gonadotropins, we studied the secretory dynamics of these hormones in eight normal ovulatory women during different phases of their menstrual cycle. All of the women demonstrated evidence...

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Published inFertility and sterility Vol. 41; no. 1; pp. 56 - 61
Main Authors Elkind-Hirsch, Karen, Ravnikar, Veronica, Tulchinsky, Dan, Schiff, Isaac, Ryan, Kenneth J.
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.01.1984
Elsevier Science
Subjects
Adult
Biological and medical sciences
Circadian Rhythm
Estradiol - blood
Female
Follicle Stimulating Hormone - blood
Fundamental and applied biological sciences. Psychology
Gonadotropin-Releasing Hormone - blood
Hormone metabolism and regulation
Humans
Luteinizing Hormone - blood
Mammalian female genital system
Menstruation
Radioimmunoassay
Reference Values
Vertebrates: reproduction
Human
Hypothalamohypophysoovarian axis
Secretion curve
Menstrual cycle
Immunoreactive form
Peptide hormone
Luteinizing hormon-releasing hormon
Hormonal investigation
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Summary:Using established radioimmunoassays for measuring plasma luteinizing hormone-releasing hormone (LH-RH) and serum gonadotropins, we studied the secretory dynamics of these hormones in eight normal ovulatory women during different phases of their menstrual cycle. All of the women demonstrated evidence of pulsatile immunoreactive LH-RH (IR-LH-RH) release throughout the cycle, with IR-LH-RH concentrations fluctuating between 0.5 and 35pg/ml in the systemic circulation. Analysis of IR-LH-RH episodic secretions revealed a significant increase of both mean IR-LH-RH concentrations (P<0.001) and pulse frequency (P<0.05) during the periovulatory period. Furthermore, plasma IR-LH-RH titers in five normal women studied during the morning and night at mid-menstrual cycle fluctuated markedly, with slightly greater episodic discharges observed during the night than in the morning (P<0.05) and no significant change in pulse frequency.
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ISSN:0015-0282
1556-5653
DOI:10.1016/S0015-0282(16)47541-2