Two new cyclopeptides from Stachys geobombycis C. Y. Wu

• Published in: Natural product research Vol. 38; no. 17; pp. 2949 - 2956
• Main Authors: Yan, Mengqi, Xian, Xiaoya, Zhou, Xianli, Liang, Chengqin
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.09.2024; Taylor & Francis Ltd
• Subjects: alpha-Glucosidases - metabolism; Amino acids; Crystallography; Crystallography, X-Ray; cyclopeptide; Glucosidase; Glycoside Hydrolase Inhibitors - chemistry; Glycoside Hydrolase Inhibitors - isolation & purification; Glycoside Hydrolase Inhibitors - pharmacology; Magnetic Resonance Spectroscopy; Mass spectrometry; Mass spectroscopy; Molecular Structure; NMR; Nuclear magnetic resonance; Peptides; Peptides, Cyclic - chemistry; Peptides, Cyclic - isolation & purification; Peptides, Cyclic - pharmacology; Plant Roots - chemistry; Stachys; Stachys - chemistry; Stachys geobombycis C. Y. Wu; X-ray crystallography; α-Glucosidase; Stachys geobombycis C. Y. Wu; α-glucosidase; cyclopeptide
• ISSN: 1478-6419; 1478-6427; 1478-6427
• DOI: 10.1080/14786419.2023.2201883

Two new cyclic peptides, named as cyclogeobomptides A (1) and B (2) were isolated from the roots of Stachys geobombycis C. Y. Wu. Compounds 1 and 2 are both made up of eight amino acids. The structures of them were established on the basis of the spectral data, including mass spectrometry, 2D NMR, and X-ray crystallography. Cyclogeobomptides A and B were proved to have obvious inhibitory activities against α-glucosidase with the IC 50 values of 26.00 and 19.16 μM, respectively.