Renal transplantation in the older recipient

From 1976 to 1983, 13 living related and 54 cadaver renal transplants were done in 62 patients more than 50 years old. Patients with no coronary or myocardial disease upon coronary angiography were selected preferentially for transplantation. Over-all 1-year patient and graft survival rates were 88...

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Bibliographic Details
Published inThe Journal of urology Vol. 134; no. 2; p. 243
Main Authors Jordan, M L, Novick, A C, Steinmuller, D, Braun, W, Buszta, C, Mintz, D, Goormastic, M, Streem, S
Format Journal Article
LanguageEnglish
Published United States 01.08.1985
Subjects
Age Factors
Antilymphocyte Serum - therapeutic use
Azathioprine - therapeutic use
Cadaver
Cardiomyopathies - complications
Coronary Disease - complications
Diabetes Complications
Follow-Up Studies
Graft Rejection
Graft Survival
Histocompatibility Testing
Humans
Hypertension - complications
Immunosuppression
Kidney Transplantation
Middle Aged
Prednisone - therapeutic use
Risk
Time Factors
Tissue Donors
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Summary:From 1976 to 1983, 13 living related and 54 cadaver renal transplants were done in 62 patients more than 50 years old. Patients with no coronary or myocardial disease upon coronary angiography were selected preferentially for transplantation. Over-all 1-year patient and graft survival rates were 88 and 70 per cent, respectively. Among cadaver recipients graft survival was improved (p less than 0.001) when prophylactic antilymphoblast globulin was used. There were fewer steroid-related complications (p less than 0.001) in recipients managed with a low dose rather than a high dose maintenance prednisone regimen. With careful patient selection and a steroid-sparing immunosuppressive regimen, renal transplantation can be done safely in older recipients with no increased risk of death or graft loss.
ISSN:0022-5347
DOI:10.1016/S0022-5347(17)47108-4