The effect of systemic treatment with platelet-activating factor on the migration of eosinophils to lung, pleural and peritoneal cavities in the guinea pig

Subcutaneous treatment of guinea pigs with platelet-activating factor (PAF) caused an increase in the prevalence of eosinophils in lavage fluid recovered from pulmonary airways, and pleural and peritoneal cavities. In PAF-treated animals, total numbers of eosinophils and macrophages in washings were...

Full description

Saved in:
Bibliographic Details
Published inInternational archives of allergy and applied immunology Vol. 95; no. 1; p. 94
Main Authors Colditz, I G, Topper, E K
Format Journal Article
LanguageEnglish
Published Switzerland 1991
Subjects
Animals
Bronchoalveolar Lavage Fluid - cytology
Cell Migration Inhibition
Cell Movement - drug effects
Eosinophils - drug effects
Eosinophils - physiology
Guinea Pigs
Lung - cytology
Male
Peritoneal Cavity - cytology
Platelet Activating Factor - pharmacology
Pleura - cytology
Online AccessGet more information

Cover

More Information
Summary:Subcutaneous treatment of guinea pigs with platelet-activating factor (PAF) caused an increase in the prevalence of eosinophils in lavage fluid recovered from pulmonary airways, and pleural and peritoneal cavities. In PAF-treated animals, total numbers of eosinophils and macrophages in washings were positively correlated, thus there was no apparent competition between the two cell types for migration at traffic sites into body cavities. The results indicate that PAF acts centrally to enhance the migration of eosinophils and monocytes into body cavities, perhaps by inducing bone marrow release of both classes of leucocytes which may then migrate constitutively into lung, pleural and peritoneal cavities.
ISSN:0020-5915
DOI:10.1159/000235461