Metabolic syndrome resolution by Roux-en-Y gastric bypass in a real world: a case control study

• Published in: Revista da Associacao Medica Brasileira (1992) Vol. 61; no. 2; pp. 161 - 169
• Main Authors: Schmid, Helena, Goelzer Neto, Claudio Fernando, Dias, Lisiane Stefani, Weston, Antonio Carlos, Espíndola, Marília Bittencourt, Pioner, Sergio Ricardo, De Carli, Luiz Alberto
• Format: Magazine Article
• Language: English
• Published: Brazil 01.03.2015
• Subjects: Adult; Body Mass Index; Brazil; Case-Control Studies; Cohort Studies; Female; Gastric Bypass - methods; Humans; Metabolic Syndrome - therapy; Obesity - metabolism; Obesity, Morbid - therapy; Retrospective Studies; Treatment Outcome; Waist Circumference; Weight Loss
• ISSN: 0104-4230; 1806-9282; 0104-4230
• DOI: 10.1590/1806-9282.61.02.161

the aim of this study was to evaluate the efficacy of Roux-en-Y Gastric Bypass (RYGB), compared with nonsurgical treatment (NS group), as an instrument for inducing remission of co-morbidities related to Metabolic Syndrome (MetS) in patients with Obesity, grades 2 and 3 (Ob2,3). two hundred and fifty eight Ob2,3 patients were selected in a retrospective analysis and included in a case control study. MetS was defined as described by the International Diabetes Federation. One hundred and twenty-nine of these patients underwent RYGB (S group), and 129 were assessed as an NS group. at baseline, S and NS groups did not differ in BMI, age, female sex and prevalence of MetS (p>0.05). For the S group the outcomes were a reduction in BMI of 38.1% (p<0.001), waist circumference of 28.6% (p<0.001), fasting plasma glucose of 10.5% (p<0.001), serum LDL-cholesterol of 21.9% (p<0.001) and of 85% in the number of patients with MetS (p<0.001). For the NS group, only a decrease of 4.12%(p=0.047) in triglyceride levels and of 5.9%(p=0.031) in Diastolic Blood Pressure was observed. In the NS group, 98.6% of the patients continued to have MetS. The number needed to treat (NNT) with surgery to resolve one case of MetS was 1.2 (CI 95%: 1.1 - 1.4). in the real world, in the South of Brazil, compared with NS treatment and after 1 year of observation, RYGB is highly effective for decreasing the prevalence of MetS.