An intercalative and minor groove binding model for the DNA cleavage reagent, copper(I) (1, 10-phenanthroline) 2

On account of the stereochemical structure and interaction characteristics of the DNA cleavage reagent copper(I) (1,10-phenanthroline) 2, both intercalative and minor groove binding modes to B-DNA could be expected to occur. In the proposed model, the suitable dihedral angle between phenanthrolines...

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Bibliographic Details
Published inJournal of theoretical biology Vol. 137; no. 1; pp. 107 - 111
Main Author Stockert, J.C.
Format Journal Article
LanguageEnglish
Published Sidcup Elsevier Ltd 07.03.1989
Elsevier
Subjects
Animals
Biological and medical sciences
Chemical Phenomena
Chemistry
Cross-Linking Reagents
DNA
Fundamental and applied biological sciences. Psychology
Interactions. Associations
Intermolecular phenomena
Models, Molecular
Molecular biophysics
Phenanthrolines
Copper Ions
Molecular interaction
Review
Molecular structure
DNA
Molecular model
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Summary:On account of the stereochemical structure and interaction characteristics of the DNA cleavage reagent copper(I) (1,10-phenanthroline) 2, both intercalative and minor groove binding modes to B-DNA could be expected to occur. In the proposed model, the suitable dihedral angle between phenanthrolines allows that one of the two planar ligands partially intercalates between base pairs, and meanwhile the other ligand locates along the minor groove.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-5193
1095-8541
DOI:10.1016/S0022-5193(89)80152-3