Biomimetic composite microspheres of collagen/chitosan/nano-hydroxyapatite: In-situ synthesis and characterization

• Published in: Materials Science & Engineering C Vol. 58; pp. 610 - 613
• Main Authors: Teng, Shu-Hua, Liang, Mian-Hui, Wang, Peng, Luo, Yong
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2016
• Subjects: Biocompatible Materials - chemical synthesis; Biocompatible Materials - chemistry; Biomaterials; Chitosan; Chitosan - chemistry; Collagen - chemistry; Collagens; Composite; Durapatite - chemistry; Hydroxyapatite; In-situ synthesis; Microspheres; Microstructure; Morphology; Nanostructure; Particle Size; Particulate composites; Synthesis; Microspheres; Composite; Microstructure; In-situ synthesis; Biomaterials
• ISSN: 0928-4931; 1873-0191
• DOI: 10.1016/j.msec.2015.09.021

The collagen/chitosan/hydroxyapatite (COL/CS/HA) composite microspheres with a good spherical form and a high dispersity were successfully obtained using an in-situ synthesis method. The FT-IR and XRD results revealed that the inorganic phase in the microspheres was crystalline HA containing carbonate ions. The morphology of the composite microspheres was dependent on the HA content, and a more desirable morphology was achieved when 20wt.% HA was contained. The composite microspheres exhibited a narrow particle distribution, most of which ranged from 5 to 10μm. In addition, the needle-like HA nano-particles were uniformly distributed in the composite microspheres, and their crystallinity and crystal size decreased with the HA content. •Collagen/chitosan/HA composites were formulated into microspheres in an emulsion.•They exhibited a regular shape, a high dispersity and a diameter range of 5–10μm.•The needle-like HA nano-particles were uniformly generated in the microspheres.•The morphology of microspheres and crystallinity of HA depend on the HA content.•The microspheres may be used for both bone regeneration and drug delivery.