A novel cell type carrying both Th and Tc/s markers in the blood of cyclosporine-treated, allografted rats

During treatment of heart-grafted rats with cyclosporine, an unusual large lymphocyte appears in the blood. These cells constitute up to 40% of the peripheral blood leukocyte population and carry both the T helper/DTH and T cytotoxic/suppressor differentiation antigens. They require both the allogra...

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Bibliographic Details
Published inTransplantation Vol. 39; no. 6; p. 624
Main Authors Godden, U, Herbert, J, Stewart, R D, Roser, B
Format Journal Article
LanguageEnglish
Published United States 01.06.1985
Subjects
Animals
Antigens, Differentiation, T-Lymphocyte
Antigens, Surface - immunology
Cyclosporins - pharmacology
Heart Transplantation
Male
Monocytes - immunology
Rats
T-Lymphocytes - cytology
T-Lymphocytes - immunology
T-Lymphocytes, Cytotoxic - cytology
T-Lymphocytes, Cytotoxic - immunology
T-Lymphocytes, Helper-Inducer - cytology
T-Lymphocytes, Helper-Inducer - immunology
T-Lymphocytes, Regulatory - cytology
T-Lymphocytes, Regulatory - immunology
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Summary:During treatment of heart-grafted rats with cyclosporine, an unusual large lymphocyte appears in the blood. These cells constitute up to 40% of the peripheral blood leukocyte population and carry both the T helper/DTH and T cytotoxic/suppressor differentiation antigens. They require both the allograft and CsA for their generation and are not recently thymus-derived. They gradually disappear after stopping CsA treatment, although the treated rats remain tolerant of the graft.
ISSN:0041-1337
DOI:10.1097/00007890-198506000-00010