Amorphous solid dispersions: Stability mechanism, design strategy and key production technique of hot melt extrusion

[Display omitted] Solid dispersion (SD) system has been used as an effective formulation strategy to increase in vitro and in vivo performances of poorly water-soluble drugs, such as solubility/dissolution, stability and bioavailability. This review provides a comprehensive SD classification and ide...

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Bibliographic Details
Published inInternational journal of pharmaceutics Vol. 646; p. 123490
Main Authors Han, Jiawei, Tang, Mengyuan, Yang, Yang, Sun, Wen, Yue, Zhimin, Zhang, Yunran, Zhu, Yijun, Liu, Xiaoqian, Wang, Jue
Format Journal Article
LanguageEnglish
Published Elsevier B.V 05.11.2023
Subjects
Classification
Design strategy
Hot melt extrusion
Solid dispersion
Stability
Hot melt extrusion
Solid dispersion
Stability
Design strategy
Classification
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Summary:[Display omitted] Solid dispersion (SD) system has been used as an effective formulation strategy to increase in vitro and in vivo performances of poorly water-soluble drugs, such as solubility/dissolution, stability and bioavailability. This review provides a comprehensive SD classification and identifies the most popular amorphous solid dispersions (ASDs). Meanwhile, this review further puts forward the systematic design strategy of satisfactory ASDs in terms of drug properties, carrier selection, preparation methods and stabilization mechanisms. In addition, hot melt extrusion (HME) as the continuous manufacturing technique is described including the principle and structure of HME instrument, key process parameters and production application, in order to guide the scale-up of ASDs and develop more ASD products to the market in pharmaceutical industry.
Bibliography:ObjectType-Article-2
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ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2023.123490