Vaccines and mucosal immunisation

The earliest attempts to protect humans against infectious diseases and toxins were by administering foreign substances to mucosal membranes, predominantly by the oral route. In the late 1880s, significant attention was given to the concept of ‘local’ immunisation, and the discipline of mucosal immu...

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Bibliographic Details
Published inVaccine Vol. 19; no. 17; pp. 2513 - 2515
Main Authors Cripps, Allan W., Kyd, Jennelle M., Foxwell, A.Ruth
Format Journal Article Conference Proceeding
LanguageEnglish
Published Oxford Elsevier Ltd 21.03.2001
Elsevier
Subjects
Administration, Oral
Applied microbiology
Biological and medical sciences
Female
Fertility
Fundamental and applied biological sciences. Psychology
Humans
Immunity, Mucosal
Immunization
Infection
Male
Microbiology
Mucosal immunisation
Patient compliance
Vaccines - administration & dosage
Vaccines - immunology
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Whole killed cell vaccine
Infection
Mucosal immunisation
Whole killed cell vaccine
Fertility
Patient compliance
Delivery system
State of the art
Local immunity
Mucosa
Scientific research
Vaccine
Case history
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Summary:The earliest attempts to protect humans against infectious diseases and toxins were by administering foreign substances to mucosal membranes, predominantly by the oral route. In the late 1880s, significant attention was given to the concept of ‘local’ immunisation, and the discipline of mucosal immunology was born in the early 1900s. However, despite the early enthusiasm, progress has been slow, with few mucosal vaccines being efficacious. The complexities of mucosal immune regulation and the lack of appropriate antigen delivery systems which can access mucosal inductive sites, have remained substantial obstacles. Recent studies demonstrating compartmentalisation of the common mucosal immune system create further challenges for the development of organ-specific vaccines. In the 21st century, our knowledge of mucosal immunoregulatory mechanisms, coupled with new technology for antigen delivery and immunomodulation will provide the necessary know–how to see the development and widespread use of mucosal vaccines for both preventative and therapeutic use.
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ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(00)00481-3