Persistence of antibody and response to booster dose of Haemophilus influenzae type b polysaccharide diphtheria toxoid conjugate vaccine in infants immunized at 9 to 15 months of age

• Published in: The Journal of pediatrics Vol. 108; no. 6; pp. 882 - 886
• Main Authors: Lepow, Martha, Randolph, Martin, Cimma, Richard, Larsen, Douglas, Rogan, Matthew, Schumacher, Jeffrey, Lent, Barbara, Gaintner, Suzanne, Samuelson, Joel, Gordon, Lance
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.06.1986; Elsevier
• Subjects: Antibodies, Bacterial - immunology; Bacterial diseases; Bacterial diseases of the respiratory system; Bacterial Vaccines - administration & dosage; Bacterial Vaccines - therapeutic use; Biological and medical sciences; Clinical Trials as Topic; Diphtheria Toxoid - administration & dosage; Diphtheria Toxoid - therapeutic use; Haemophilus influenzae - immunology; Human bacterial diseases; Humans; Immunization, Secondary; Immunologic Memory; Infant; Infectious diseases; Medical sciences; Polysaccharides - administration & dosage; Human; Infection; Haemophilus influenzae B; Respiratory disease; Immunological investigation; Immunotherapy; Vaccination; Bacteriosis; Infant; ENT disease; Diphtheria; Polyvalent vaccine
• ISSN: 0022-3476; 1097-6833
• DOI: 10.1016/S0022-3476(86)80921-0

At approximately 2 years of age, 27 infants prevlously immunized at 9 to 15 months of age with two doses of polyribosylribifol phosphate-diphtheria toxoid conjugate vaccine (PRP-D) and 23 infants immunized with polyribosyiribitol phosphate (PRP) vaccine were given a single injection of PRP-D. Pre- and post-immunization sera were obtained. No serious local or systemic reactions were observed. The PRP-D reciplents had a geometric mean anti-PRP antibody level of 4.8 μg/ml 1 month after the second primary injection, retained 1.2 μg/ml 1 year later, and had a level of 71 μg/ml after the booster immunization. In contrast, PRP recipients had a geometric mean level of 0.083 μg/ml 1 month after the second primary injection, retained 0.042 μg/ml 1 year later, and after a single dose of PRP-D at approximately 2 years of age had a geometric mean level of 8.6 μg/ml. The significantly higher antibody response in the prior PRP-D recipients suggests the recall of immunologic memory induced by the PRP-D vaccine.