Protection conferred against Junin virus infection in rats

2-day-old Wistar rats intracerebrally infected with the XJC13 strain of virus exhibited a 5% survival rate which rose to 71% after immune serum treatment. Brain viral titers were relatively unaffected by this treatment. Histologic studies showed necrosis in the cerebellum and brain cortex with monon...

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Bibliographic Details
Published inIntervirology Vol. 21; no. 3; p. 174
Main Authors Blejer, J L, Galassi, N V, Saavedra, V M, Nejamkis, M R
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1984
Subjects
Animals
Arenaviridae - immunology
Arenaviruses, New World - immunology
Brain - pathology
Disease Models, Animal
Hemorrhagic Fever, American - pathology
Hemorrhagic Fever, American - prevention & control
Immunization Schedule
Immunization, Passive
Necrosis
Rats
Rats, Inbred Strains
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Summary:2-day-old Wistar rats intracerebrally infected with the XJC13 strain of virus exhibited a 5% survival rate which rose to 71% after immune serum treatment. Brain viral titers were relatively unaffected by this treatment. Histologic studies showed necrosis in the cerebellum and brain cortex with mononuclear cell infiltration in both treated and nontreated groups. Beginning on day 16 postinfection, however, intracerebral perivascular gliosis foci and mild meningeal congestion were minimal in the treated animals. These findings imply that passively transferred humoral immunity leads to prompt recovery in this experimental model.
ISSN:0300-5526
DOI:10.1159/000149516