New potential of the reductive alkylation of amines

Available data on the reductive alkylation of amines with carbonyl compounds - a key method for the preparation of secondary and tertiary amines - are described systematically. The review provides information on the relevant reducing agents and catalysts and on the use of chiral catalysts in stereo-...

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Bibliographic Details
Published inRussian chemical reviews Vol. 84; no. 3; pp. 288 - 309
Main Authors Gusak, K N, Ignatovich, Zh V, Koroleva, E V
Format Journal Article
LanguageEnglish
Published Turpion Ltd and the Russian Academy of Sciences 01.01.2015
Subjects
Amines
Carbonyl compounds
Catalysis
Catalysts
Information dissemination
Reducing agents
Reductive alkylation
Synthesis (chemistry)
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Summary:Available data on the reductive alkylation of amines with carbonyl compounds - a key method for the preparation of secondary and tertiary amines - are described systematically. The review provides information on the relevant reducing agents and catalysts and on the use of chiral catalysts in stereo- and enantiocontrolled reactions of amine synthesis. The effect of the reactant and catalyst structures on the reaction rates and chemo- and stereo(enantio)selectivity is considered. The bibliography includes 156 references.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0036-021X
1468-4837
DOI:10.1070/RCR4443