Chemical Diversity of Liverworts From Frullania Genus

Frullania is one of the largest and taxonomically most complex genus of leafy liverworts. Current morphology-based estimates of Frullania diversity are close to 400 species; however, species level-classification of Frullania has been regarded notoriously difficult and subject to many studies. The li...

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Bibliographic Details
Published inNatural product communications Vol. 16; no. 2
Main Authors Ludwiczuk, Agnieszka, Asakawa, Yoshinori
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.02.2021
Subjects
chemotypes
eudesmanolides
sesquiterpene lactones
bibenzyls
liverworts
Frullania
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Summary:Frullania is one of the largest and taxonomically most complex genus of leafy liverworts. Current morphology-based estimates of Frullania diversity are close to 400 species; however, species level-classification of Frullania has been regarded notoriously difficult and subject to many studies. The liverworts classified in this genus have been studied using morphological evidence and molecular markers but also in terms of secondary metabolite composition. Up to now 98 Frullania species have been chemically investigated. As a result, it is known that Frullania species are characterized by a remarkable chemical diversity. The most characteristic compounds present in this liverwort genus are sesquiterpene lactones with eudesamnolides as the most diverse group, and aromatic compounds belonging to bibenzyls. In this review paper we report the distribution of secondary metabolites in all chemically investigated Frullania species and discuss some aspects concerning the division of this genus into chemotypes.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X21995381