Correlation of IL-12, IL-22, and IL-23 in patients with psoriasis and metabolic syndrome. Preliminary report

• Published in: Cytokine (Philadelphia, Pa.) Vol. 85; pp. 130 - 136
• Main Authors: Brito-Luna, M.J., Villanueva-Quintero, D.G., Sandoval-Talamantes, A.K., Fafutis-Morris, M., Graciano-Machuca, O., Sanchez-Hernandez, P.E., Alvarado-Navarro, A.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.09.2016
• Subjects: Adult; Case-Control Studies; Female; Humans; Interleukin-12 - blood; Interleukin-22; Interleukin-23 - blood; Interleukins - blood; Male; Metabolic syndrome; Metabolic Syndrome - blood; Middle Aged; Plaque psoriasis; Pro-inflammatory cytokines; Psoriasis - blood; Tumor Necrosis Factor-alpha - blood; Pro-inflammatory cytokines; Metabolic syndrome; Plaque psoriasis
• ISSN: 1043-4666; 1096-0023
• DOI: 10.1016/j.cyto.2016.06.020

•Serum IL-12 were more elevated in PP group than HS group.•Serum IL-22 was found to be higher in PP group than in PPMS group.•We found no correlation between cytokine levels and psoriasis nor with PASI scores.•In PP group a positive correlation was observed between IL-23 and fasting glucose.•In PP group negative correlation between IL-22 and IL-12 with waist circumference. Psoriasis is an autoimmune skin disease characterised by proliferation of keratinocytes, primarily due to cytokines Th1 and Th17. This profile is involved in pathogenesis of metabolic syndrome, a frequently found comorbidity in patients with psoriasis. In this study we determine the correlation of levels of pro-inflammatory cytokines TNF-α, IL-23, IL-12, and IL-22 in patients with psoriasis with and without metabolic syndrome and clinically healthy controls. We included 55 patients with plaque psoriasis: 30 with metabolic syndrome (PPMS), 25 without metabolic syndrome (PP), 15 healthy subjects (HS) and 15 with metabolic syndrome (MS). Quantification of serum levels of IL-12, TNF-α, IL-22, and IL-23 was done by ELISA. We observed that serum levels of IL-12 were more elevated in PP group, while the lowest levels of TNF-α were seen in HS group. IL-22 was found to be higher in PP than in PPMS (p<0.05). PP patients with PASI scores rating as severe showed higher levels of IL-12. TNF-α level analysis showed significant differences in HS group compared with the others; levels of this cytokine were lower in patients with PP and moderate PASI scores than in MS group (p<0.05). We found no correlation between cytokine levels and psoriasis or between cytokines and PASI scores. In PP group, a positive correlation was observed between IL-23 and fasting glucose (r=0.432, p<0.05), as well as a negative correlation between IL-23, IL-22, and IL-12 versus waist circumference (r=−0.504, r=−0.556 and r=−0.511, respectively; p<0.05). Psoriasis is not just a skin disorder, but rather a condition with systemic implications, with intervention of pro-inflammatory cytokines that contribute to metabolic syndrome and other comorbidities, which in turn increases the risk of developing cardiovascular disease.