Synthesis and antitumor activity of novel paclitaxel–chlorambucil hybrids

• Published in: Bioorganic & medicinal chemistry letters Vol. 11; no. 6; pp. 811 - 814
• Main Authors: Wittman, Mark D., Kadow, John F., Vyas, Dolatrai M., Lee, Francis L., Rose, William C., Long, Byron H., Fairchild, Craig, Johnston, Kathy
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 26.03.2001; Elsevier
• Subjects: Animals; Antineoplastic agents; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - therapeutic use; Antineoplastic Agents, Alkylating - chemistry; Antineoplastic Agents, Alkylating - pharmacology; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - pharmacology; Biological and medical sciences; Chemotherapy; Chlorambucil - chemistry; Chlorambucil - pharmacology; Disease Models, Animal; Female; Humans; Inhibitory Concentration 50; Medical sciences; Mice; Neoplasm Transplantation; Ovarian Neoplasms - drug therapy; Paclitaxel - chemistry; Paclitaxel - pharmacology; Pharmacology. Drug treatments; Sarcoma - drug therapy; Tumor Cells, Cultured; Xenograft Model Antitumor Assays; Antineoplastic agent; Human; Terpenoid; Intravenous administration; Antitubulin; Cytotoxicity; In vitro; Biological activity; Chlorambucil; Acetal; In vivo; Alkylating agent; Chemotherapy; Experimental disease; Cell line; Treatment; Animal; Paclitaxel; Diterpene; Colon; Chemical synthesis; Antimitotic
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/S0960-894X(01)00067-1

The syntheses and antitumor activity of three paclitaxel–chlorambucil hybrids are presented. Hybrid 3 showed significant in vivo efficacy. The syntheses and antitumor activity of three paclitaxel–chlorambucil hybrids are presented. Hybrid 3 showed significant in vivo efficacy.