Lack of influence of diethylstilbestrol on induced pancreatic ductal carcinomas in Syrian hamsters

• Published in: Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie Vol. 47; no. 2; pp. 117 - 120
• Main Authors: Baum, Anke, Kamino, Kenji, Chan Son, Woo, Ernst, Heinrich
• Format: Journal Article
• Language: English
• Published: Jena Elsevier GmbH 01.05.1995; Elsevier
• Subjects: Adenocarcinoma - chemically induced; Adenocarcinoma - etiology; Adenocarcinoma - pathology; Animals; Biological and medical sciences; Carcinogenesis, pancreatic; Carcinogens; Cricetinae; Diethylstilbestrol (DES); Diethylstilbestrol - toxicity; Exocrine pancreas, carcinoma; Female; Gastroenterology. Liver. Pancreas. Abdomen; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Mesocricetus; N-nitrosobis-(2-oxopropyl)amine (BOP); Nitrosamines; Pancreas exocrine, carcinoma; Pancreatic Neoplasms - chemically induced; Pancreatic Neoplasms - etiology; Pancreatic Neoplasms - pathology; Sex Factors; Tumors; Carcinogenesis, pancreatic; Pancreas exocrine, carcinoma; Diethylstilbestrol (DES); N-nitrosobis-(2-oxopropyl)amine (BOP); Exocrine pancreas, carcinoma; Adenocarcinoma; Rodentia; Malignant tumor; Carcinogenesis; Pathology; Vertebrata; Experimental disease; Mammalia; Animal; Digestive diseases; Sex steroid hormone; Pancreas; Hamster; Pancreatic disease
• ISSN: 0940-2993; 1618-1433
• DOI: 10.1016/S0940-2993(11)80296-4

Syrian golden hamsters were treated with N-nitrosobis-(2-oxopropyl)amine (BOP) and/or diethylstilbestrol (DES) for lifetime. After BOP treatment the hamsters developed high incidences of pancreatic neoplasms, but DES failed to show any effect on these or other tumours.