Effect of the sulfonylurea glyburide on superoxide dismutase in streptozotocin-induced diabetic rat muscle

• Published in: General pharmacology Vol. 28; no. 5; pp. 795 - 796
• Main Authors: Altan, Nilgün, Yigit, Şükrü, Elmali, Esra, Malhatun, Erdinç, Rota, Simin, Kiliç, Nedret
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.05.1997; Elsevier
• Subjects: Animals; Biological and medical sciences; Blood Glucose - metabolism; Body Weight - drug effects; diabetes mellitus; Diabetes Mellitus, Experimental - drug therapy; Diabetes Mellitus, Experimental - enzymology; Diabetes Mellitus, Experimental - physiopathology; Diabetes Mellitus, Type 2 - enzymology; General and cellular metabolism. Vitamins; Glyburide; Glyburide - pharmacology; Hypoglycemic Agents - pharmacology; Male; Medical sciences; Muscle, Skeletal - drug effects; Muscle, Skeletal - enzymology; Pharmacology. Drug treatments; Rats; superoxide dismutase; Superoxide Dismutase - metabolism; superoxide dismutase; diabetes mellitus; Glyburide; Endocrinopathy; Rat; Enzyme; Diabetes mellitus; Rodentia; Oral administration; Smooth muscle; Superoxide dismutase; Soleus muscle; Long term; Biological activity; Vertebrata; Chemotherapy; Hypoglycemic agent; Experimental disease; Mammalia; Treatment; Enzymatic activity; Animal; Sulfonylureas; Oxidoreductases; Glibenclamide; Mechanism of action
• ISSN: 0306-3623; 1879-0011
• DOI: 10.1016/S0306-3623(96)00355-2

1. 1. The effect of glyburide (glibenclamide) treatment on the muscle superoxide dismutase (SOD) activity of diabetic rats has been studied. 2. 2. Four weeks of treatment with glyburide (5 mg/kg, orally) increased muscle SOD activity and decreased blood glucose levels. 3. 3. The results of this study demonstrate that the sulfonylurea, glyburide, is capable of exerting direct insulinlike effects on muscle SOD activity in vivo.