Macrophages are involved in age-dependent resistance of rats to Junin virus infection

We attempted to correlate rat age with resistance to intraperitoneal infection with the XJ strain of Junin virus. Accordingly, mortality, viral replication in macrophages and brain, as well as neutralizing antibody (NA) levels were recorded in animals inoculated at 2, 5, 10 and 26 days of life. Two-...

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Bibliographic Details
Published inIntervirology Vol. 27; no. 2; p. 117
Main Authors Blejer, J L, Remesar, M C, Nejamkis, M R
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1987
Subjects
Aging
Animals
Antibodies, Viral - analysis
Arenaviridae - physiology
Arenaviruses, New World - immunology
Arenaviruses, New World - physiology
Brain - microbiology
Hemorrhagic Fever, American - immunology
Hemorrhagic Fever, American - microbiology
Immunity, Innate
Macrophages - microbiology
Rats
Rats, Inbred BUF
Vero Cells
Virus Replication
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Summary:We attempted to correlate rat age with resistance to intraperitoneal infection with the XJ strain of Junin virus. Accordingly, mortality, viral replication in macrophages and brain, as well as neutralizing antibody (NA) levels were recorded in animals inoculated at 2, 5, 10 and 26 days of life. Two-day-old animals demonstrated both the greatest mortality (86%) and viral replication in macrophages, allowing virus to reach the brain where high titers were detected. This age group also had the highest NA titers. Mortality, viral multiplication and NA titers diminished with increasing age of the animals. The ability of peritoneal macrophages to support viral replication, therefore, seems to determine rat susceptibility to intraperitoneal infection with Junin virus.
ISSN:0300-5526
DOI:10.1159/000149729