Pure Erythroleukemia (Variant Acute Myeloid Leukemia-vAML-M6) with Deletion of Chromosome 20, Mainly Presenting as Late Erythroblasts, a Unique Case Report with Review of Literature

• Published in: Indian journal of hematology & blood transfusion Vol. 30; no. 1; pp. 34 - 37
• Main Authors: Rasool, Javid, Geelani, Sajad, Khursheed, Yasir, Lone, Mohd Suhail, Shaban, Mohd
• Format: Journal Article
• Language: English
• Published: India Springer India 01.03.2014; Springer Nature B.V
• Subjects: Blood Transfusion Medicine; Case Report; Case studies; Chromosomes; Erythrocytes; Hematology; Human Genetics; Leukemia; Medicine; Medicine & Public Health; Oncology; Deletion 20q; Pure erythroleukemia; Late erythroblasts
• ISSN: 0971-4502; 0974-0449; 0974-0449; 0971-4502
• DOI: 10.1007/s12288-012-0180-9

Acute erythroleukemia is characterized by a predominant immature erythroid population and accounts for approximately 2–5 % of all cases of acute leukemia. Two subtypes are recognized based on the presence or absence of a significant myeloid component: erythroleukemia and pure erythroid leukemia. Erythroleukemia is predominantly a disease of adults, while pure erythroid leukemia can be seen in any age including children. Here is a case of pure erythroleukemia presenting mainly as late erythroblasts which was diagnosed on bone marrow examination, cytochemistry and was confirmed on immunophenotyping. Possibly this is the only case so for demonstrating deletion of long arm of chromosome 20 in pure erythroleukemia.