Characterization of a new human bladder cancer cell line, UCRU-BL-28

• Published in: The Journal of urology Vol. 150; no. 3; p. 1038
• Main Authors: Russell, P J, Palavidis, Z, Rozinova, E, Philips, J, Wills, E J, Lukeis, R, Wass, J, Raghavan, D
• Format: Journal Article
• Language: English
• Published: United States 01.09.1993
• Subjects: Biomarkers, Tumor - biosynthesis; Carcinoma, Transitional Cell - genetics; Carcinoma, Transitional Cell - metabolism; Carcinoma, Transitional Cell - pathology; Cell Division; Humans; Karyotyping; Ploidies; Tumor Cells, Cultured - metabolism; Tumor Cells, Cultured - pathology; Urinary Bladder Neoplasms - genetics; Urinary Bladder Neoplasms - metabolism; Urinary Bladder Neoplasms - pathology
• ISSN: 0022-5347
• DOI: 10.1016/S0022-5347(17)35682-3

A new human bladder cancer cell line, UCRU-BL-28 has been established and characterized from a relapsed, cisplatin resistant, grade II, stage T4 tumor. This line is tumorigenic in nude mice and reflects the pathology of the original tumor. The morphology, the expression of tumor-associated antigens and EGF receptors, and the ability to grow both in an anchorage independent manner and in the absence of serum is explored. The BL-28 line has 71-74XXY chromosomes, with del 5q, der(9) and i(19q). Further studies on the molecular basis of bladder cancer, chemosensitivity to cisplatin, growth factor production and tissue invasion are under way.