Electrodermal potential and conductance measurements clinically discriminate between cystic fibrosis and control patients

• Published in: Pediatric research Vol. 19; no. 8; pp. 810 - 814
• Main Authors: WILLIAMSON, P. S, FOWLES, D. C, WEINBERGER, M
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.08.1985
• Subjects: Adolescent; Adult; Asthma - diagnosis; Asthma - physiopathology; Biological and medical sciences; Child; Child, Preschool; Cystic Fibrosis - diagnosis; Cystic Fibrosis - physiopathology; Female; Galvanic Skin Response - physiology; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Other diseases. Semiology; Sex Ratio; Human; Screening; Mucoviscidosis; Respiratory disease; Electrodermography; Digestive diseases; Electrical conductance; Diagnostic; Exploration; Pancreatic disease
• ISSN: 0031-3998; 1530-0447
• DOI: 10.1203/00006450-198508000-00006

To evaluate the adaptation of electrodermal techniques for cystic fibrosis screening, skin surface bioelectric measurements were recorded from 37 established cystic fibrosis patients, 45 asthmatic patients, and 10 normal controls, ranging in age from 6 to 22 yr. Six skin potential and six skin conductance measures of sweat gland activity without the collection of sweat distinguished between the cystic fibrosis, normal, and asthmatic groups (F ratios greater than 10.0; p less than 0.0001). Discriminant analysis using the two best electrodermal measures (the mean of five preresponse potential levels and the mean of five preresponse conductance levels for each subject) to assign experimental group membership matched actual group membership with 92.7% accuracy. We believe these results warrant further investigation of electrodermal procedures as a direct, simple, yet noninvasive means of screening for cystic fibrosis.