Association between polymorphisms of Xeroderma pigmentosum complementation group C gene (XPC) and susceptibility to schizophrenia

• Published in: Gene Vol. 695; pp. 99 - 100
• Main Authors: Taghipour, Nahid, Saadat, Iraj, Saadat, Mostafa
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 05.05.2019
• Subjects: Alleles; Case-control; DNA damage; DNA Damage - genetics; DNA repair; DNA Repair - genetics; DNA-Binding Proteins - genetics; Female; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; haplotypes; Haplotypes - genetics; Humans; Male; photosensitivity disorders; Polymorphism, Single Nucleotide - genetics; Risk; Risk Factors; schizophrenia; Schizophrenia - genetics; Schizophrenia - pathology; statistical analysis; OR; CI; HWE; Risk; XPC; DNA repair; Case-control
• ISSN: 0378-1119; 1879-0038; 1879-0038
• DOI: 10.1016/j.gene.2019.02.018

Previous studies revealed that polymorphisms in several DNA repair genes are associated with the risk of schizophrenia. The relationship between three polymorphisms (Ala499Val, PAT, and Lys939Gln) of the XPC (MIM: 613208) and the risk of schizophrenia is investigated. A total of 361 schizophrenia cases and 360 healthy controls were included in the study. Statistical analysis revealed that the Ala/Val genotype (OR = 0.62, P = 0.004) and the carriers of the Val allele (OR = 0.64, P = 0.006) were negatively associated with the risk of schizophrenia. The other two examined polymorphisms did not reveal significant association. The “Val - Lys” haplotype was associated with decrease risk of schizophrenia (OR = 0.71, P = 0.020). It has been showed that the haplotype “Val - Lys” had the lowest DNA damages, indicating that has higher DNA repair capacity. Here we found that this haplotype is associated with lower risk for schizophrenia. •Xeroderma pigmentosum complementation group C involved in nucleotide excision repair.•The XPC has several genetic variants including Ala499Val, Lys939Gln, and PAT.•Association between these polymorphisms and risk of schizophrenia was investigated.•The present study was carried out on 361 schizophrenia subjects and 360 healthy controls.•The “Val - Lys” haplotype was associated with decrease risk of schizophrenia.