Transitional cell carcinoma of the vagina with pagetoid spread pattern

A distinctive variant of a papillary noninvasive transitional cell carcinoma (TCC) of the vagina removed from a postmenopausal woman is described. The neoplasm was evaluated by immunohistochemistry. The designation of this neoplasm as a TCC is supported by its morphological features and its coexpres...

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Bibliographic Details
Published inHuman pathology Vol. 29; no. 3; pp. 299 - 301
Main Authors Singer, Gad, Hohl, Michael K, Hering, Franz, Anabitarte, Manuel
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.03.1998
Elsevier
Subjects
Adult
Biological and medical sciences
Carcinoma, Transitional Cell - metabolism
Carcinoma, Transitional Cell - pathology
Carcinoma, Transitional Cell - surgery
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
Immunohistochemistry
Keratins - metabolism
Medical sciences
Metaplasia
Neoplasm Recurrence, Local - pathology
Neoplasm Recurrence, Local - surgery
Neoplasms, Second Primary - metabolism
Neoplasms, Second Primary - pathology
Neoplasms, Second Primary - surgery
pagetoid spread pattern
Postmenopause
transitional cell carcinoma
transitional cell metaplasia
Tumors
Urinary Bladder Neoplasms - pathology
Urinary Bladder Neoplasms - surgery
vagina
Vagina - pathology
Vaginal Neoplasms - metabolism
Vaginal Neoplasms - pathology
Vaginal Neoplasms - surgery
vagina
transitional cell metaplasia
TCC
CK
pagetoid spread pattern
immunohistochemistry
transitional cell carcinoma
TCM
Case study
Human
Immunohistochemistry
Pathology
Dissemination
Postmenopause
Vagina
Vaginal diseases
Female
Malignant tumor
Transitional cell carcinoma
Female genital diseases
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Summary:A distinctive variant of a papillary noninvasive transitional cell carcinoma (TCC) of the vagina removed from a postmenopausal woman is described. The neoplasm was evaluated by immunohistochemistry. The designation of this neoplasm as a TCC is supported by its morphological features and its coexpression for cytokeratin (CK) 7 and CK 20. Its main feature is pagetoid infiltration into adjacent vaginal epithelium. This is the second reported case involving a transitional cell metaplasia (TCM) of the vagina, a possible precursor lesion of the TCC.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
ObjectType-Article-3
ISSN:0046-8177
1532-8392
DOI:10.1016/S0046-8177(98)90051-X