Altered cerebral energy utilization in late life depression

Background: Global and regional changes in cerebral energy utilization are reported to characterize late life depression. Methods: Twenty seven subjects with late life depression (9 prior to starting medication, 18 after starting) and 27 matched controls were evaluated with cordance, a quantitative...

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Published inJournal of affective disorders Vol. 49; no. 2; pp. 89 - 99
Main Authors Cook, Ian A, Leuchter, Andrew F, Uijtdehaage, Sebastian H.J, Osato, Sheryl, H. Holschneider, Daniel, Abrams, Michelle, Rosenberg-Thompson, Susan
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 01.05.1998
Elsevier
Subjects
Age Factors
Aged
Biological and medical sciences
Brain - diagnostic imaging
Brain - metabolism
Cordance
Depressive Disorder - diagnosis
Depressive Disorder - psychology
EEG
Electroencephalography
Energy Metabolism - physiology
Female
Functional Laterality
Geriatrics
Humans
Late life depression
Major depression
Male
Medical sciences
Physiology
Psychiatric Status Rating Scales
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Tomography, Emission-Computed
Physiology
Cordance
Major depression
Late life depression
EEG
Human
Mood disorder
Electrical activity
Central nervous system
Electrophysiology
Depression
Electroencephalography
Elderly
Brain (vertebrata)
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Summary:Background: Global and regional changes in cerebral energy utilization are reported to characterize late life depression. Methods: Twenty seven subjects with late life depression (9 prior to starting medication, 18 after starting) and 27 matched controls were evaluated with cordance, a quantitative EEG measure that reflects cerebral energy utilization. Results: Global and focal (anterior and centrotemporal) differences were present in theta-band cordance between unmedicated depressed and control subjects. Depressed subjects receiving treatment had cordance patterns similar to controls. Conclusions: The presence of both diffuse and focal disturbances in energy utilization prior to initiating treatment indicates that cordance detects altered cerebral physiology in depressed patients, and that this measure may also be sensitive to treatment interventions.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0165-0327
1573-2517
DOI:10.1016/S0165-0327(97)00192-4