Differential gene expression in tumor adjacent histologically normal prostatic tissue indicates field cancerization

• Published in: International journal of oncology Vol. 35; no. 3; pp. 537 - 546
• Main Authors: HAALAND, C. M, HEAPHY, C. M, BUTLER, K. S, FISCHER, E. G, GRIFFITH, J. K, BISOFFI, M
• Format: Journal Article
• Language: English
• Published: Athens Editorial Academy of the International Journal of Oncology 01.09.2009
• Subjects: Aged; Biological and medical sciences; Gene Expression; Gene Expression Profiling; Humans; Male; Medical sciences; Middle Aged; Oligonucleotide Array Sequence Analysis; Prostate - pathology; Prostatic Neoplasms - genetics; Prostatic Neoplasms - pathology; Reverse Transcriptase Polymerase Chain Reaction; Tumors; tumor adjacent histologically normal; Cancerology; Tumoral tissue; Tumor; Gene expression; Urogenital system; Prostate; Field cancerization

Field cancerization denotes the occurrence of aberrant cells in tumor adjacent histologically normal tissues (TAHN). To characterize field cancerization in prostate cancer, we used RNA from paired patient tumor and TAHN tissues excised at 1 cm from the tumor margin and subjected them to microarray e...