Perinatal hypothyroidism decreases hippocampal mossy fiber zinc density in rats

The effect of perinatal hypothyroidism on hippocampal mossy fiber zinc density was examined in rats. Timed pregnant Sprague-Dawley rat dams were given water containing either 0.02% propylthiouracil (PTU) or vehicle from gestational day 18 until their litters were weaned on postnatal day 31. Hippocam...

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Bibliographic Details
Published inNeuroendocrinology Vol. 55; no. 1; p. 20
Main Authors Savage, D D, Otero, M A, Montano, C Y, Razani-Boroujerdi, S, Paxton, L L, Kasarskis, E J
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1992
Subjects
Animals
Animals, Newborn
Female
Hippocampus - metabolism
Hippocampus - pathology
Histological Techniques
Hypothyroidism - metabolism
Male
Organ Size - physiology
Rats
Spectrophotometry, Atomic
Zinc - metabolism
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Summary:The effect of perinatal hypothyroidism on hippocampal mossy fiber zinc density was examined in rats. Timed pregnant Sprague-Dawley rat dams were given water containing either 0.02% propylthiouracil (PTU) or vehicle from gestational day 18 until their litters were weaned on postnatal day 31. Hippocampal mossy fiber zinc density was reduced by 75% in both the dorsal and ventral hippocampal formation CA3 stratum lucidum region of 31-day-old PTU-treated rats compared to untreated controls. Perinatal hypothyroidism did not alter hippocampal tissue zinc concentration, indicating that the PTU-induced reduction in mossy fiber zinc was not a consequence of reduced hippocampal zinc concentration. At 120 days of age, 3 months after discontinuation of PTU treatment, hippocampal mossy fiber zinc density remained significantly reduced by 33-45% in PTU-treated rats compared to control. These data indicate that perinatal hypothyroidism causes a long-lasting reduction in hippocampal mossy fiber zinc density.
ISSN:0028-3835
DOI:10.1159/000126092