Effect of extracorporeal shock wave lithotripsy on prostate specific antigen

• Published in: The Journal of urology Vol. 156; no. 5; p. 1682
• Main Authors: Colombo, T, Zigeuner, R, Altziebler, S, Pummer, K, Stettner, H, Hubmer, G
• Format: Journal Article
• Language: English
• Published: United States 01.11.1996
• Subjects: Adult; Aged; Aged, 80 and over; Humans; Lithotripsy; Male; Middle Aged; Prostate-Specific Antigen - blood; Ureteral Calculi - blood; Ureteral Calculi - therapy
• ISSN: 0022-5347
• DOI: 10.1016/S0022-5347(01)65482-X

We evaluated the effects of extracorporeal shock wave lithotripsy (ESWL) of distal ureteral calculi on serum prostate specific antigen (PSA). A total of 29 consecutive men with distal ureteral calculi at a maximum of 25 mm. from the ureteral orifice, and without any history of urinary tract infection, benign prostatio hyperplasia or prostate cancer underwent ESWL with the Dornier MPL 9000 X lithotriptor. The therapeutic focus size was 48 X 7 mm. PSA was measured exactly 5 minutes before ESWL, as well as 120 minutes, 24 hours and 7 days after termination of treatment. Fragmentation rate was 100% and all patients were stone-free within 1 week of therapy. There was no statistically significant difference between PSA values before and after treatment. Only 15 patients had a slight increase in PSA at 120 minutes after treatment (range 0.01 to 0.41 ng./ml., mean 0.07). ESWL can be performed in men at risk for prostate cancer without impairing the predictive value of PSA.