Ectopic bone formation with the help of growth factor bFGF

• Published in: Journal of cranio-maxillo-facial surgery Vol. 24; no. 5; pp. 300 - 304
• Main Authors: Wiltfang, J., Merten, H.-A.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.10.1996; Elsevier
• Subjects: Adipose Tissue; Animals; Biological and medical sciences; Bone Marrow Transplantation; Bone Substitutes; Bone Transplantation; Cattle; Degeneration. Regeneration. Wound healing. Graft; Dentistry; Durapatite; Female; Fibroblast Growth Factor 2 - pharmacology; Fundamental and applied biological sciences. Psychology; Neovascularization, Physiologic; Osteogenesis - drug effects; Periosteum - transplantation; Polyglactin 910; Prostheses and Implants; Swine; Swine, Miniature; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Fibroblast growth factor; Adipose tissue; Cytokine; Exploration; Histology; Experimental study; Angiogenesis; Vertebrata; Mammalia; Polypeptide; Animal; Artiodactyla; Ectopia; Bone; Minipig; Morphometry; Application; Cicatrization; Formation; Ungulata; Growth factor
• ISSN: 1010-5182; 1878-4119
• DOI: 10.1016/S1010-5182(96)80063-1

In the present study, basic fibroblast growth factor and a non-resorbable biological matrix (Endobon 1 ) were used to help to induce ectopic bone formation in the subdermal fatty tissue of the Göttingen miniature pig. In the early phase, bFGF improved the recipient conditions by enhancing angioneogenesis and helping to provide pluripotent mesenchymal cells. However, vitally transplanted bone cells were necessary in order to ensure successful bone formation. The Endobon only served as an osteoconductive matrix. 1 Fa. E. Merck, Darmstadt, Germany.