Clear cell adenocarcinoma of the urethra: evidence for origin within paraurethral ducts

We report a case of clear cell adenocarcinoma arising in a paraurethral duct treated by anterior pelvic exenteration. Immunohistochemical stains for prostate specific acid phosphatase and prostate specific antigen were positive in the primary tumor and regional metastases. Focal positive staining al...

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Bibliographic Details
Published inThe Journal of urology Vol. 143; no. 1; p. 122
Main Authors Spencer, J R, Brodin, A G, Ignatoff, J M
Format Journal Article
LanguageEnglish
Published United States 01.01.1990
Subjects
Adenocarcinoma - pathology
Aged
Aged, 80 and over
Female
Humans
Urethra - pathology
Urethral Neoplasms - pathology
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Summary:We report a case of clear cell adenocarcinoma arising in a paraurethral duct treated by anterior pelvic exenteration. Immunohistochemical stains for prostate specific acid phosphatase and prostate specific antigen were positive in the primary tumor and regional metastases. Focal positive staining also was noted in normal paraurethral duct epithelium. Our observations suggest that clear cell adenocarcinoma arises from the female paraurethral ducts, rather than embryonic remnants. These ducts appear to be homologous to the prostate and in some cases may be misinterpreted as urethral diverticula.
ISSN:0022-5347
DOI:10.1016/S0022-5347(17)39887-7