The role of adaptor proteins in lymphocyte activation

• Published in: Molecular Immunology Vol. 41; no. 6; pp. 615 - 630
• Main Authors: Togni, Mauro, Lindquist, Jon, Gerber, Annegret, Kölsch, Uwe, Hamm-Baarke, Andrea, Kliche, Stefanie, Schraven, Burkhart
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2004
• Subjects: Adaptor proteins; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport - immunology; Adaptor Proteins, Vesicular Transport - physiology; Animals; B-lymphocytes; Carrier Proteins - immunology; Carrier Proteins - physiology; Cell activation; Cell adhesion; Humans; Lymphocytes - immunology; Lymphocytes - physiology; Membrane Proteins - immunology; Membrane Proteins - physiology; Phosphoproteins - immunology; Phosphoproteins - physiology; Proteins - immunology; Proteins - physiology; Signal transduction; T-lymphocytes; LAX; TRIM; PLC; ADAP/SLAP-130/Fyb; RapL; Signal transduction; Cell activation; RBD; TBSMs; AICD; ITAMs; Cell adhesion; NTAL/LAB; XLP; PSMACs; Adaptor proteins; SLP-76; TRAPs; PAG/Cbp; PTKs; ITIM; PTPase; T-lymphocytes; B-lymphocytes; LIME; SKAP-HOM; LAT; SIT; SKAP-55
• ISSN: 0161-5890; 1872-9142; 1365-2567
• DOI: 10.1016/j.molimm.2004.04.009

Research within the last 10 years has provided compelling evidence that adaptor proteins regulate the major pathways of lymphocyte activation. Based upon their differential subcellular localization, transmembrane adaptors and cytosolic adaptors can be distinguished. Here we review some of the most recent findings about both types of adaptor proteins which have facilitated our understanding how immunoreceptors control lymphocyte activation and differentiation.