Chemical composition and anti-proliferative activity of essential oils from some medicinal plants from Cachicadán, Región La Libertad, Perú

• Published in: Natural product research Vol. 38; no. 12; pp. 2145 - 2150
• Main Authors: Vaca Meza, Eveleny Tirsa, Vasquez-Kool, Jorge, Costilla Sánchez, Noé Ildefonso, Vieira, Amandio, Rodrigues, Rodney Alexandre Ferreira, Sartoratto, Adilson, Flores Granados, Angela del Pilar, Marin Tello, Carmen Luisa, Ruiz, Ana Lucia Tasca Gois
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 17.06.2024; Taylor & Francis Ltd
• Subjects: Acyclic Monoterpenes - pharmacology; Alkenes; anti-proliferative activity; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - pharmacology; Antiproliferatives; Bicyclic Monoterpenes - chemistry; Bicyclic Monoterpenes - pharmacology; Breast cancer; Carvone; Cell Line, Tumor; Cell Proliferation - drug effects; Chemical composition; clonogenic cell assay; Cyclohexane Monoterpenes; Dihydrocarvone; Essential oils; Flowers - chemistry; Gas chromatography; Gas Chromatography-Mass Spectrometry; Geranial; Herbal medicine; Humans; In vitro evaluation; In vivo methods and tests; Leaves; Limonene; Limonene - pharmacology; Linalool; Mass spectrometry; Mass spectroscopy; MCF-7 Cells; Medicinal plants; monoterpenes; Monoterpenes - chemistry; Monoterpenes - pharmacology; Myrcene; Neral; Ocimene; Oils, Volatile - chemistry; Oils, Volatile - pharmacology; Piperitone; Plant Leaves - chemistry; Plants, Medicinal - chemistry; sesquiterpenes; Terpenes - chemistry; Terpenes - pharmacology; Tumor cells; α-Pinene; anti-proliferative activity; In vitro evaluation; monoterpenes; clonogenic cell assay; sesquiterpenes
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2023.2238114

This study evaluated the chemical composition and anti-proliferative activity of essential oils (EOs) obtained by hydrodistillation from seven medicinal plants from Cachicadán, La Libertad Región, Perú. Limonene (0.64 to 44.43%) and linalool (0.36 to 2.12%) were identified in all EOs by gas chromatography coupled to mass spectrometry analysis. The major components (relative intensity ≥ 10%) were cis-dihydro carvone, carvone, and cis-piperitone epoxide for Minthostachys mollis leaves; β-pinene, limonene, and ledol for Lepechinia heteromorpha leaves; limonene, neral, and geranial for Aloysia citriodora, both leaves and flowers; α-pinene, and limonene for Myrcianthes myrsinoides leaves; and α-pinene, β-myrcene, and (E)-β-Ocimene for Dalea carthagenensis leaves. Constituted by (Z)-β-ocimene, dihydrotagetone, (Z)-tagetone, and car-3-en-2-one, EO of Tagetes minuta leaves induced an irreversible cytostatic effect against MCF-7 human breast tumor cells. Further in vivo studies must be carried out to establish the safe and efficient dose of T. minuta EO as adjuvant treatment in oncological therapies.