Treatment of nevus comedonicus with ammonium lactate lotion

• Published in: Journal of the American Academy of Dermatology Vol. 20; no. 2; pp. 324 - 328
• Main Authors: Milton, Gayle P., DiGiovanna, John J., Peck, Gary L.
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.02.1989; Elsevier
• Subjects: Administration, Topical; Adult; Ammonia - administration & dosage; Ammonia - therapeutic use; Biological and medical sciences; Combined Modality Therapy; Dermatology; Epidermal Cyst - etiology; Epidermal Cyst - surgery; Humans; Keratosis - drug therapy; Keratosis - pathology; Lactates - administration & dosage; Lactates - therapeutic use; Lactic Acid; Male; Medical sciences; Nevus - drug therapy; Nevus - pathology; Ointments; Tumors of the skin and soft tissue. Premalignant lesions; Human; Lactates; Ammonium; Comedo nevus; Skin disease; Treatment; Nevus; Tumor; Percutaneous route
• ISSN: 0190-9622; 1097-6787
• DOI: 10.1016/S0190-9622(89)70039-6

A patient with an extensive nevus comedonicus, which is associated frequently with the development of large inflammatory cysts and abscesses within the nevus, responded dramatically within 1 month to a once-daily application of 12% ammonium lactate lotion. A marked beneficial effect on the comedonal component of the nevus was noted. One inflammatory cyst has developed in an area left untreated by the patient, but none have occurred in treated areas since therapy with ammonium lactate lotion was begun. Previous treatments, which were either ineffective or of minimal effectiveness, included oral isotretinoin, topical tretinoin, salicylic acid, lactic acid, and d-tartaric acid creams.