Outcomes of primary phakic trabeculectomies without versus with 0.5- to 1-minute versus 3- to 5-minute mitomycin C

• Published in: American journal of ophthalmology Vol. 126; no. 6; pp. 755 - 762
• Main Authors: Kim, Yong Y, Sexton, Rebecca M, Shin, Dong H, Kim, Chaesik, Ginde, Savita A, Ren, Jianming, Lee, Damho, Kupin, Talya H
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.12.1998; Elsevier
• Subjects: Aged; Biological and medical sciences; Female; Glaucoma, Open-Angle - drug therapy; Glaucoma, Open-Angle - surgery; Humans; Intraocular Pressure - drug effects; Lens, Crystalline; Male; Medical sciences; Middle Aged; Mitomycin - administration & dosage; Mitomycin - adverse effects; Mitomycin - therapeutic use; Ocular Hypotension - chemically induced; Postoperative Complications - chemically induced; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the eye and orbit; Time Factors; Trabeculectomy - methods; Treatment Outcome; Vision Disorders - chemically induced; Visual Acuity - drug effects; Human; Trabeculectomy; Chemotherapy; Mitomycin; Antimetabolic; Surgery; Combined treatment; Exposure time; Comparative study
• ISSN: 0002-9394; 1879-1891
• DOI: 10.1016/S0002-9394(98)00279-7

PURPOSE: To compare the intraocular pressure and hypotony outcomes of primary phakic trabeculectomies with no mitomycin C (MMC), shorter MMC, and longer MMC exposure. METHODS: We evaluated primary phakic trabeculectomies with no MMC (36 eyes of 36 patients), 0.5- to 1-minute MMC (50 eyes of 50 patients), and 3- to 5-minute MMC (38 eyes of 38 patients) at the concentration of 0.5 mg/ml. Successful trabeculectomy was defined as an intraocular pressure of 21 mm Hg or less without development of a marked visual acuity loss associated with prolonged hypotony (intraocular pressure < 6 mm Hg over 3 months) and without the need for additional surgery to control intraocular pressure or treat postoperative complications. RESULTS: The three groups were similar in demographics, preoperative intraocular pressure, and medical dependency. However, the incidence of hypotony during the postoperative periods of 3 to 12 months was significantly higher in the 3- to 5-minute MMC group ( P < .05, chi-square test). Severe visual acuity loss associated with hypotony was also more frequently found in the 3- to 5-minute MMC group than in the 0.5- to 1-minute ( P = .009, chi-square test) group or the control group ( P = .014, chi-square test). In addition, the success probabilities were significantly different among the three groups ( P = .001, Kaplan-Meier survival analysis with log-rank test) and were the highest in the 0.5- to 1-minute MMC group and the lowest in the 3- to 5-minute MMC group. CONCLUSION: Shorter application (0.5 to 1 minute) of MMC appears to be optimal for the successful outcome of primary phakic trabeculectomy compared with no MMC or longer application of MMC at a concentration of 0.5 mg/ml.