Synthesis and in vitro cytotoxicity of C(20)( RS)-camptothecin analogues modified at both B (or A) and E ring

A series of C(7) and C(20)-substituted camptothecin derivatives ( 12 – 14, 16 – 18) are prepared. Their syntheses and in vitro cytotoxicities are reported. A series of C(7) and C(20)-substituted camptothecin derivatives ( 12–14, 16–18) are prepared. Their syntheses and in vitro cytotoxicities are re...

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Published inBioorganic & medicinal chemistry letters Vol. 8; no. 14; pp. 1797 - 1800
Main Authors Jew, Sang-sup, Kim, Myoung Goo, Kim, Hee-Jin, Rho, Eun-Young, Park, Hyeung-geun, Kim, Joon-Kyum, Han, Hyun-Jung, Lee, Heesoon
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 21.07.1998
Elsevier
Subjects
Antineoplastic agents
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - pharmacology
Biological and medical sciences
Camptothecin - analogs & derivatives
Camptothecin - chemical synthesis
Camptothecin - pharmacology
General aspects
Humans
Medical sciences
Pharmacology. Drug treatments
Structure-Activity Relationship
Tumor Cells, Cultured
Antineoplastic agent
Human
Diol
Lactam
Polycyclic compound
Cytotoxicity
Lactone
L1210-Leukemia
In vitro
Structure activity relation
Chlorine Organic compounds
Established cell line
Chemical synthesis
Tumor cell
Oxygen nitrogen heterocycle
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Summary:A series of C(7) and C(20)-substituted camptothecin derivatives ( 12 – 14, 16 – 18) are prepared. Their syntheses and in vitro cytotoxicities are reported. A series of C(7) and C(20)-substituted camptothecin derivatives ( 12–14, 16–18) are prepared. Their syntheses and in vitro cytotoxicities are reported.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(98)00317-5