Prothrombotic inherited abnormalities other than factor v leiden mutation do not play a role in venous thrombosis in inflammatory bowel disease

• Published in: The American journal of gastroenterology Vol. 96; no. 5; pp. 1448 - 1454
• Main Authors: Guédon, C, Le Cam-Duche, V, Lalaude, O, Ménard, J.F, Lerebours, E, Borg, J.Y
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Inc 01.05.2001; Blackwell Publishing
• Subjects: Adult; Aged; Biological and medical sciences; Factor V; Female; Fibrin Fibrinogen Degradation Products - analysis; Gastroenterology. Liver. Pancreas. Abdomen; Gene Frequency; Humans; Inflammatory Bowel Diseases - blood; Inflammatory Bowel Diseases - genetics; Male; Medical sciences; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation - physiology; Other diseases. Semiology; Oxidoreductases Acting on CH-NH Group Donors - genetics; Protein S - analysis; Prothrombin - genetics; Reference Values; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Venous Thrombosis - genetics; Human; Abnormal coagulation factor; Cardiovascular disease; Statistical study; Thrombosis; Genetic disease; Inflammatory disease; Venous disease; Vascular disease; Crohn disease; Risk factor; Digestive diseases; Intestinal disease; Complication; Mutation; Vein; Coagulopathy; Ulcerative colitis
• ISSN: 0002-9270; 1572-0241
• DOI: 10.1016/S0002-9270(01)02360-7

OBJECTIVES: Because the incidence of thromboembolism is increased in patients with inflammatory bowel disease, we attempted to assess the role of prothrombotic inherited coagulation abnormalities in the development of thrombosis. METHODS: Four populations were compared: 15 patients with inflammatory bowel disease and a previous venous thrombosis, 58 control patients with inflammatory bowel disease but without thrombosis, 110 patients without inflammatory bowel disease but with previous deep venous thrombosis, and 84 healthy subjects. Inherited and acquired risk factors of venous thrombosis, e.g., factor V Leiden and prothrombin 20210A mutations, C677T methylenetetrahydrofolate reductase polymorphism, a polymorphism located in exon 13 of factor V gene, inflammatory and hypercoagulability markers were studied in each population. RESULTS: In the study, 14.3% of thrombotic patients with inflammatory bowel disease had factor V Leiden mutation versus 0% of control patients with inflammatory bowel disease ( p = 0.04), 15.5% of thrombotic patients without inflammatory bowel disease (NS) and 3.6% of the healthy controls. A total of 14% of thrombotic patients with inflammatory bowel disease and 11.8% of thrombotic patients without inflammatory bowel disease carried prothrombin 20210A mutation, compared to 1.7% of control patients with inflammatory bowel disease; however, the difference was just below significance. Other inherited coagulation abnormalities were not statistically significantly different among the four populations. CONCLUSIONS: Our study confirms that factor V Leiden mutation increases the risk for thrombotic events but is not more frequent in patients with inflammatory bowel disease. Our results do not support the role of other thrombotic risk factors.