Asymmetric Angioneurotic Edema Associated With Thrombolysis for Acute Stroke

• Published in: Annals of emergency medicine Vol. 30; no. 2; pp. 227 - 229
• Main Authors: Pancioli, Arthur, Brott, Thomas, Robertson, Virginia, Miller, Rosie
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.08.1997; Elsevier
• Subjects: Acute Disease; Angioedema - chemically induced; Angioedema - physiopathology; Biological and medical sciences; Cerebrovascular Disorders - drug therapy; Cerebrovascular Disorders - physiopathology; Drug toxicity and drugs side effects treatment; Female; Humans; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Recombinant Proteins - adverse effects; Thrombolytic Therapy - adverse effects; Tissue Plasminogen Activator - adverse effects; Toxicity: skin, dermoskeleton; Human; Immunopathology; Allergy; Nervous system diseases; Stroke; Toxicity; Acute; Cardiovascular disease; Fibrinolysis; Cerebral disorder; Genetic disease; Vascular disease; Case study; Chemotherapy; Angioneurotic edema; Alteplase; Treatment; Asymmetry; Central nervous system disease; Complication; Cerebrovascular disease; Fibrinolytic
• ISSN: 0196-0644; 1097-6760
• DOI: 10.1016/S0196-0644(97)70147-1

We present a case of acute asymmetric angioneurotic edema associated with the use of recombinant tissue plasminogen activator (rtPA) for acute ischemic stroke. rtPA was administered for an acute ischemic stroke in accordance with the recently reported National Institute of Neurological Disorders and Stroke protocol, after which marked asymmetric angioedema requiring upper-airway control developed. Although atypical and anaphylactoid reactions have been reported with the use of rtPA for acute myocardial infarction, to our knowledge this is the first case report of asymmetric angioedema associated with the use of rtPA for acute ischemic stroke. [Pancioli A, Brott T, Donaldson V, Miller R: Asymmetric angioneurotic edema associated with thrombolysis for acute stroke. Ann Emerg Med August 1997;30:227-229.]