Effects of intravesical instillation of antitumor chemotherapeutic and immunotherapeutic agents on bladder lesion development in rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine

• Published in: The Journal of urology Vol. 138; no. 5; p. 1305
• Main Authors: Okamura, T, Ohtani, M, Inoue, K, Fukushima, S, Ohtaguro, K, Kakizoe, T
• Format: Journal Article
• Language: English
• Published: United States 01.11.1987
• Subjects: Administration, Intravesical; Animals; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological Products - therapeutic use; Bleomycin - administration & dosage; Butylhydroxybutylnitrosamine - toxicity; Cisplatin - administration & dosage; Drug Evaluation, Preclinical; Drug Interactions; Epithelium - drug effects; Epithelium - pathology; Female; Nitrosamines - toxicity; Picibanil - therapeutic use; Precancerous Conditions - chemically induced; Precancerous Conditions - drug therapy; Precancerous Conditions - pathology; Rats; Rats, Inbred F344; Time Factors; Urinary Bladder - drug effects; Urinary Bladder - pathology; Urinary Bladder Neoplasms - chemically induced; Urinary Bladder Neoplasms - drug therapy; Urinary Bladder Neoplasms - pathology
• ISSN: 0022-5347
• DOI: 10.1016/S0022-5347(17)43589-0

The effects of 12 weeks of intravesical instillation of bleomycin, cisplatinum and picibanyl on development of urinary bladder tumors and preneoplastic lesions were examined in rats pretreated with N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) for four weeks. Upon sacrifice at week 36, histopathological examination revealed a significantly reduced incidence of PN hyperplasia and a tendency for decreased papilloma generation in rats given cisplatinum. However, the other treatments were not associated with any effect on carcinogen-induced lesion development. The results demonstrate that cisplatinum has a potential for postinitiation inhibition of rat bladder carcinogenesis.