Familial uveal melanoma

Because familial occurrences of uveal melanoma are rare, there have only been 15 cases of familial melanoma reported in the literature. We studied 11 additional families with a total of 24 members, in which two or more members were afflicted with uveal melanoma. The median age at diagnosis was 56.5...

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Bibliographic Details
Published inAmerican journal of ophthalmology Vol. 117; no. 4; p. 516
Main Authors Young, L H, Egan, K M, Walsh, S M, Gragoudas, E S
Format Journal Article
LanguageEnglish
Published United States 15.04.1994
Subjects
Adult
Aged
Aged, 80 and over
Choroid Neoplasms - genetics
Choroid Neoplasms - therapy
Eye Enucleation
Female
Humans
Male
Melanoma - genetics
Melanoma - therapy
Middle Aged
Neoplasms - genetics
Pedigree
Survival Rate
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Summary:Because familial occurrences of uveal melanoma are rare, there have only been 15 cases of familial melanoma reported in the literature. We studied 11 additional families with a total of 24 members, in which two or more members were afflicted with uveal melanoma. The median age at diagnosis was 56.5 years, similar to the median age at diagnosis of the remaining patients treated in our institution. Thirteen were male and 11 were female, which is consistent with the slight predominance of males found in many large surveys of patients with uveal melanoma. There is a possibility of a heritable component present in these families.
ISSN:0002-9394
DOI:10.1016/S0002-9394(14)70014-5