Long-term survivors of pediatric heart transplantation: A multicenter report of sixty-eight children who have survived longer than five years

• Published in: The Journal of pediatrics Vol. 130; no. 6; pp. 862 - 871
• Main Authors: Sigfússon, Gunnlaugur, Fricker, F.Jay, Bernstein, Daniel, Addonizio, Linda J., Baum, David, Hsu, Daphne T., Chin, Clifford, Miller, Susan A., Boyle, Gerard J., Miller, Joan, Lawrence, Kathy S., Douglas, Judith F., Griffith, Bartley P., Reitz, Bruce A., Michler, Robert E., Rose, Eric A., Webber, Steven A.
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.06.1997; Elsevier
• Subjects: Adolescent; Biological and medical sciences; Child; Child, Preschool; Coronary Disease - diagnosis; Graft Rejection - drug therapy; Heart Transplantation; Hemodynamics; Humans; Hypertension - etiology; Immunosuppression - adverse effects; Immunosuppressive Agents - adverse effects; Immunosuppressive Agents - therapeutic use; Infant; Kidney Diseases - etiology; Kidney Diseases - physiopathology; Lymphoproliferative Disorders - diagnosis; Lymphoproliferative Disorders - etiology; Medical sciences; Pulmonary Wedge Pressure; Quality of Life; Replantation; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the heart; Survivors; Human; Heart; Immunopathology; Evaluation; Multicenter study; Cardiovascular disease; Transplantation; Homotransplantation; Coronary heart disease; Long term; Survival; Retrospective; Quality of life; Immunosuppression; Surgery; Complication; Child
• ISSN: 0022-3476; 1097-6833
• DOI: 10.1016/S0022-3476(97)70270-1

Objective: Short-term survival after pediatric heart transplantation is now excellent, but ultimately the efficacy of this procedure will depend on duration and quality of survival. We sought to evaluate the clinical course of long-term survivors of heart transplantation in childhood. Methods: Patients who had undergone heart transplantation at the university hospitals of Stanford, Columbia, and Pittsburgh between 1975 and 1989 and survived longer than 5 years from transplantation were identified and their clinical courses retrospectively reviewed. Results: Sixty eight children have survived more than 5 years from transplantation, and 60 (88%) are currently alive with a median follow-up of 6.8 years (5 to 17.9 years). Thirteen have survived more than 10 years from transplantation. Renal dysfunction caused by immunosuppressive agents was common, and two patients required late renal transplantation. Lymphoproliferative disease or other neoplasm occurred in 12 patients, but none resulted in death. Coronary artery disease was diagnosed in 13 patients (19%), leading to retransplantation in eight. Death after 5 years was related to acute or chronic rejection in 5 of 8 cases. Two of the deaths were directly related to noncompliance with immunosuppressive medication (Table). All survivors are in New York Heart Association class 1. Conclusions: Long-term survival with good quality of life can be achieved after heart transplantation in childhood, though complications of immunosuppression remain common. Posttransplantation coronary artery disease is emerging as the main factor limiting long term graft and patient survival. (J Pediatr 1997; 130:862-71)