Sequential Birch reaction and asymmetric Ir-catalyzed hydrogenation as a route to chiral building blocks

A range of 1,2,4-trisubstituted cyclohexadienes obtained from the Birch reaction were hydrogenated asymmetrically to produce synthetically valuable chiral compounds in high enantio- and diastereoselectivity.

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 47; no. 13; pp. 3989 - 3991
Main Authors Paptchikhine, Alexander, Itto, Kaori, Andersson, Pher G.
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.01.2011
Subjects
Alkadienes - chemistry
Biochemistry
Biokemi
Catalysis
Chemistry
Chemistry, Multidisciplinary
Hydrogenation
Iridium - chemistry
Kemi
NATURAL SCIENCES
NATURVETENSKAP
Physical Sciences
Science & Technology
Stereoisomerism
N,P LIGANDS
OLEFINS
REDUCTION
PYRIDINE
IRIDIUM CATALYSTS
COMPLEXES
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Summary:A range of 1,2,4-trisubstituted cyclohexadienes obtained from the Birch reaction were hydrogenated asymmetrically to produce synthetically valuable chiral compounds in high enantio- and diastereoselectivity.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/c0cc05619g