Extracellular Axon Stimulation

This is a detailed protocol explaining how to perform extracellular axon stimulations as described in Städele and Stein, 2016. The ability to stimulate and record action potentials is essential to electrophysiological examinations of neuronal function. Extracellular stimulation of axons traveling in...

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Bibliographic Details
Published inBio-protocol Vol. 7; no. 5; p. e2151
Main Authors Städele, Carola, DeMaegd, Margaret Louise, Stein, Wolfgang
Format Journal Article
LanguageEnglish
Published United States Bio-Protocol 05.03.2017
Bio-protocol LLC
Subjects
Biology
Methods
Action potentials
Neuron
Anode
Cathode
Electrophysiology
Artifact
Threshold
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Summary:This is a detailed protocol explaining how to perform extracellular axon stimulations as described in Städele and Stein, 2016. The ability to stimulate and record action potentials is essential to electrophysiological examinations of neuronal function. Extracellular stimulation of axons traveling in fiber bundles (nerves) is a classical technique in brain research and a fundamental tool in neurophysiology (Abbas and Miller, 2004; Barry, 2015; Basser and Roth, 2000; Cogan, 2008). It allows for activating action potentials in individual or multiple axons, controlling their firing frequency, provides information about the speed of neuronal communication, and neuron health and function.
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ISSN:2331-8325
2331-8325
DOI:10.21769/BioProtoc.2151