Novel cytokine release inhibitors. Part II: Steroids

• Published in: Bioorganic & medicinal chemistry letters Vol. 8; no. 20; pp. 2825 - 2828
• Main Authors: Wei He, Huang, Fu-Chih, Morytko, Michael, Jariwala, Navin, Yu, Kin-Tak
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 20.10.1998; Elsevier
• Subjects: Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - pharmacology; Biological and medical sciences; Bones, joints and connective tissue. Antiinflammatory agents; Cells, Cultured; Humans; Inhibitory Concentration 50; Interleukin-1 - antagonists & inhibitors; Interleukin-1 - metabolism; Medical sciences; Monocytes - drug effects; Monocytes - metabolism; Pharmacology. Drug treatments; Steroids - chemistry; Steroids - pharmacology; Structure-Activity Relationship; Human; Steroid; Chemical rearrangement; Monocyte; Antiinflammatory agent; Cytokine; Alcohol; Interleukin 1β; In vitro; Androstane derivatives; Structure activity relation; Phenols; Aromatic compound; Inhibitor; Chemical synthesis; Acylate
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/S0960-894X(98)00521-6

Steroidal derivatives as IL-1β release inhibitors are discussed. Steroidal derivatives as IL-1β release inhibitors are discussed.